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Tranexamic Acid for Spot & Melasma Treatment: At-Home Formulation Guide

Dermatology's New Favorite: Tranexamic Acid

Tranexamic Acid (TXA) has become one of the most talked-about active ingredients in the dermatology world in recent years for the treatment of melasma and stubborn blemishes. It inhibits plasminogen activator, thereby suppressing melanocyte activation, making it extremely effective, especially for hormonally induced spots (melasma).

Why Tranexamic Acid?

  • Clinically proven efficacy for melasma and hormonal spots
  • Safer than hydroquinone, suitable for long-term use
  • Works synergistically with Alpha Arbutin and Niacinamide
  • Available in both water-soluble and oil-soluble forms
  • Remains stable over a wide pH range

Tranexamic Acid Spot Serum Formula (100 grams)

Ingredient Ratio (%) Phase
Distilled Water 71% Water Phase
Glycerin 5% Water Phase
Pentylene Glycol 3% Water Phase
Tranexamic Acid 3% Water Phase
Niacinamide 5% Water Phase
Alpha Arbutin 2% Cold Phase
Low Mol. Hyaluronic Acid 1% Water Phase
Xanthan Gum Soft Clear 0.4% Water Phase
Microcare DB 1% Cold Phase
pH Adjustment q.s. Cold Phase

Manufacturing Steps

  1. Pre-swell Xanthan Gum in glycerin.
  2. Mix water phase components (water, Pentylene Glycol, HA, Niacinamide, TXA).
  3. Add Xanthan mixture and homogenize.
  4. Add Alpha Arbutin and Microcare DB below 40°C.
  5. Adjust pH to 5.5-7.0.

Usage Protocol

Apply to cleansed skin morning and evening. Results usually begin to appear after 4-8 weeks of regular use. Always use SPF during the day.